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Evidence summary for pain management during retinopathy of prematurity screening

Chunlan Tao1, Jinghua Tang1, Jing Tu1

  • 1Department of Neonatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.

Frontiers in Pediatrics
|February 2, 2026
PubMed

Insights

Effective pain management during retinopathy of prematurity (ROP) screening is crucial for preterm infants. This study provides evidence-based recommendations for combined pharmacological and non-pharmacological interventions to minimize infant pain.

Area of Science:

  • Neonatal care
  • Ophthalmology
  • Pain management

Background:

  • Retinopathy of prematurity (ROP) is a primary cause of childhood blindness.
  • Screening for ROP in preterm infants is essential but can cause procedural pain.
  • This study addresses pain management strategies during ROP screening.

Purpose of the Study:

  • To summarize the best evidence for managing pain during ROP screening.
  • To provide clinical practice guidance for medical staff.
  • To improve the care of high-risk preterm infants.

Main Methods:

  • Systematic literature search of guidelines, reviews, and consensus statements up to October 2024.
  • Independent quality evaluation of included articles by multiple reviewers.
  • Extraction and grading of evidence, leading to evidence-based recommendations.

Main Results:

  • Eighteen articles were included, yielding 92 pieces of evidence.
  • Evidence was categorized into pain management teams, assessment, non-pharmacological, pharmacological interventions, and documentation.
  • Twenty-five evidence-based recommendations were formulated.

Conclusions:

  • Best evidence strategies offer actionable guidance for ROP screening pain management.
  • Medical staff training in neonatal pain management is recommended.
  • Combined pharmacological and non-pharmacological interventions are advised to alleviate pain.
Abstract

Keywords:
evidence–based practiceinfantmass screeningpain managementprematureretinopathy of prematurity

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