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Updated: Feb 4, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Temporal epilepsy associated with hippocampal focal cortical dysplasia
Thi Phuoc Yen Tran1, The Khanh Dang2, Nu Tra My Ton3
1Department of Neurosurgery, Vinmec Central Park International Hospital, Ho Chi Minh, Vietnam.
Background:
Focal cortical dysplasia (FCD) is a congenital abnormality of the cerebral cortex and a common cause of epilepsy. However, FCD in the hippocampus is rare.
Case Description:
A 30-year-old woman was admitted to the hospital because of seizures. Brain magnetic resonance imaging showed focal cortical thickening of the right medial temporal lobe cortex. The patient underwent a right-sided anteromedial temporal lobectomy. Pathologic examination showed disorganized cortical gray matter tissue with large dysmorphic cortical neurons, supporting a FCD diagnosis. The histological findings of hippocampal sclerosis were not found.
Conclusion:
The present case is a rare case of dysmorphic neurons without histological findings of sclerosis in the hippocampus reported. Recognizing more hippocampal FCD-related epilepsy cases is essential to better understanding the condition.
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