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Applications of micro/nano drug delivery systems in cancer pain management

Shizhen Geng1, Yurou Zhang2, Zhehao Zhang3

  • 1Department of Anesthesiology, Pain and Perioperative Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Bioactive Materials
|February 2, 2026
PubMed

Insights

Micro/nano drug delivery systems (MNDDs) offer advanced solutions for cancer pain management, overcoming limitations of traditional analgesics. These systems provide targeted delivery and controlled release for improved therapeutic effects and reduced toxicity.

Area of Science:

  • Oncology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Cancer pain significantly impacts patient quality of life and treatment efficacy.
  • Existing analgesics have limitations including tolerance, addiction, and systemic toxicity.
  • Multifactorial pathophysiology of cancer pain necessitates novel therapeutic strategies.

Purpose of the Study:

  • To review the pathophysiology of cancer pain.
  • To analyze limitations of current analgesic treatments.
  • To summarize advances in micro/nano drug delivery systems (MNDDs) for cancer pain.

Main Methods:

  • Comprehensive literature review of cancer pain mechanisms.
  • Critical analysis of pharmacological constraints of conventional analgesics.
  • Summary of recent developments in engineered MNDDs.

Main Results:

  • MNDDs show promise for precise targeting (tumor and neuropathic pathways).
  • MNDDs enable controlled drug release and multi-modal synergistic effects.
  • Engineered MNDDs offer potential for toxicity-minimized analgesic interventions.

Conclusions:

  • MNDDs represent a promising strategy for effective cancer pain management.
  • Further development of multifunctional MNDDs is crucial for precision analgesia.
  • A multidisciplinary approach is needed to advance MNDD-based cancer pain therapies.
Keywords:
Cancer painDrug deliveryMicro/nano drug delivery systemsTargeted interventions

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