Related Experiment Video

Updated: Feb 4, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

9.5K

Improving the bioavailability of nintedanib by formulating inhalable ufasomes as a targeted therapy for non-small

Salman M Ghazwani1, Sami Alhazmi2, Salhah M Ghazwani3

  • 1Department of Surgery, Faculty of Medicine, Jazan University, Saudi Arabia.

International Journal of Pharmaceutics: X
|February 2, 2026
PubMed

Insights

Nebulized nintedanib ufasomes (NLU) offer improved lung cancer treatment. This novel formulation enhances nintedanib

Area of Science:

  • Pharmacology
  • Drug Delivery Systems
  • Oncology

Background:

  • Nintedanib is used for non-small cell lung cancer (NSCLC).
  • Nintedanib has poor oral bioavailability due to low solubility and first-pass metabolism.
  • There is a need for improved drug delivery methods for nintedanib in NSCLC treatment.

Purpose of the Study:

  • To develop and evaluate nebulized nintedanib ufasomes (NLU) for enhanced NSCLC therapy.
  • To improve nintedanib's sustainability, targeting, bioavailability, and effectiveness.

Main Methods:

  • Formulation optimization using Design Expert software.
  • Evaluation of NLU aerodynamics, cytotoxicity, bioavailability, and targeting.
  • In vivo efficacy and safety study in a Lewis lung carcinoma (LLC) mouse model.

Main Results:

  • NLU significantly increased nintedanib's sustainability (49.5%), bioavailability (6.63-fold), and targeting (8.99-fold).
  • NLU reduced the IC50 value by 4.7-fold.
  • Nebulized NLU demonstrated superior anti-tumor, anti-inflammatory, and anti-oxidative effects compared to oral nintedanib.

Conclusions:

  • Nebulized nintedanib ufasomes (NLU) represent a promising targeted therapy for NSCLC.
  • The optimal NLU formulation at 100 mg/kg is safe and effective.
  • NLU overcomes the limitations of oral nintedanib, offering enhanced therapeutic potential.
Keywords:
BioavailabilityLewis lung carcinomaLung cancerNintedanibTargeting

More Related Videos

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

413
Using Computer-based Image Analysis to Improve Quantification of Lung Metastasis in the 4T1 Breast Cancer Model08:32

Using Computer-based Image Analysis to Improve Quantification of Lung Metastasis in the 4T1 Breast Cancer Model

Published on: October 2, 2020

7.0K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.3K
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
801
Bioavailability: Overview01:17

Bioavailability: Overview

Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...
434
Bioavailability: Overview01:13

Bioavailability: Overview

Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
4.4K