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In the field of psychology, there are several ways to organize measurements of a trait, feature, or characteristic (i.e., variables). Qualitative data, such as ethnicity, can be tabulated into a frequency count to provide information about the proportion, as well as the variety of groups in a sample or population. On the other hand, researchers can perform a wider set of calculations on quantitative data. The mean, mode, and median, for instance, are central tendency measures to identify a...
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Confirming the normal range for Mebrofenin liver function indices.

Kathy P Willowson1,2, Geoff Schembri1, Elizabeth A Bailey1

  • 1Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, Australia.

Asia Oceania Journal of Nuclear Medicine & Biology
|February 2, 2026
PubMed
Summary
This summary is machine-generated.

This study establishes normal ranges for technetium-99m mebrofenin hepatobiliary scintigraphy (HBS) liver function indices. The mebrofenin liver uptake rate normalized to body-surface-area (MURBSA) is approximately 8.0±1.5 %/min/m², with a lower limit of normal at 5.1 %/min/m².

Keywords:
Hepatobiliary scintigraphyLiverMebrofeninPortal vein embolisation Radioembolisation

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Area of Science:

  • Nuclear Medicine
  • Diagnostic Imaging
  • Hepatobiliary System

Background:

  • Hepatobiliary scintigraphy (HBS) using technetium-99m mebrofenin is crucial for assessing liver function.
  • Establishing reliable normal ranges and understanding measurement uncertainty are vital for accurate clinical interpretation.

Purpose of the Study:

  • To define normal ranges for [99mTc] Tc-Mebrofenin HBS indices of liver function.
  • To quantify the uncertainty in clinical measures associated with region placement in HBS.
  • To investigate the correlation between liver function indices and patient age.

Main Methods:

  • 47 patients without liver disease underwent dynamic HBS with [99mTc] Tc-Mebrofenin.
  • Blood pool clearance rate, blood clearance half-time, mebrofenin liver uptake rate (MUR), and MUR normalized to body-surface-area (MURBSA) were calculated.
  • Intra-user variability and uncertainty were assessed through repeated measurements.

Main Results:

  • The mean MURBSA for the cohort was 8.0±1.5 %/min/m², with a lower limit of normal established at 5.1 %/min/m².
  • No significant correlation was found between liver function indices and patient age.
  • Clinical measures of MURBSA were found to have an uncertainty of ±0.6 %/min/m².

Conclusions:

  • The normal range for MURBSA is approximately 8.0±1.5 %/min/m², with a lower limit of 5.1 %/min/m².
  • MURBSA values below the established normal limit may indicate higher risk in patients undergoing liver surgery or treatment.
  • Accurate HBS index ranges are essential for risk stratification in liver disease management.