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Updated: Feb 4, 2026

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How Does Plasma Therapy Approach Affect VDR Expression in the Elderly?

Ender Deniz Asmaz1, Hikmet Taner Teker2, Taha Ceylani3

  • 1Department of Histology and Embryology, Ankara Medipol University Faculty of Medicine, Ankara, Türkiye.

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Summary
This summary is machine-generated.

Young plasma therapy improved digestion and increased vitamin D receptor (VDR) expression in aged rats. This supports organ regeneration and hormonal renewal, counteracting age-related decline.

Keywords:
Histomorphologyimmunohistochemistryjejunumplasma therapyvitamin D receptor

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Area of Science:

  • Gerontology
  • Regenerative Medicine
  • Gastroenterology

Background:

  • Young plasma contains rejuvenating factors that decline with age, impacting organ regeneration and hormonal function.
  • Vitamin D receptor (VDR) expression decreases with aging, potentially affecting physiological processes.
  • Plasma therapy is explored as a method to restore youthful factors and counteract aging effects.

Purpose of the Study:

  • To investigate the effects of young plasma therapy on jejunal histomorphology and VDR levels in aged rats.
  • To assess the potential of plasma therapy for organ regeneration and hormonal support.

Main Methods:

  • Aged Wistar rats received pooled plasma from young rats.
  • Histomorphological parameters (villus height, mucosal thickness, crypt depth, surface area) of the jejunum were measured.
  • Vitamin D receptor (VDR) expression was quantified using immunohistochemistry.

Main Results:

  • Plasma therapy increased jejunal crypt depth compared to young controls.
  • Both young plasma therapy and young controls showed improvements in histomorphological and VDR parameters versus aged controls.
  • No significant differences were observed in villus height, mucosal thickness, or surface area between young plasma-treated and young control groups.

Conclusions:

  • Young plasma therapy enhances parameters supporting digestion and increases VDR expression in aged rats.
  • This suggests a beneficial influence of plasma therapy on counteracting age-related declines.