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Synthesis and Catalytic Performance of Gold Intercalated in the Walls of Mesoporous Silica
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Controlled Cisplatin Delivery Using pH-Sensitive PAA-Grafted Mesoporous Silica Nanoparticles
Raana Kashfi Sadabad1, Sheyda Ranjbar1, Mittal Darji1
1Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Storrs, Connecticut 06269, United States.
ACS Omega
|February 2, 2026
Summary
New nanoparticle formulations improve cisplatin delivery for ovarian cancer metastasis. Poly-(acrylic acid)-modified mesoporous silica nanoparticles (Pt-PAA-MSNs) enhance drug retention and efficacy in the peritoneal cavity, offering a promising treatment strategy.
Area of Science:
- Nanotechnology
- Materials Science
- Oncology
Background:
- Ovarian cancer frequently metastasizes to the peritoneal cavity, posing significant treatment challenges.
- Current treatments involve intravenous (IV) or intraperitoneal (IP) cisplatin, but suffer from low drug retention at tumor sites.
- Nanoparticle-based drug delivery systems offer potential solutions to improve therapeutic outcomes.
Purpose of the Study:
- To develop and evaluate novel nanoparticle formulations for enhanced cisplatin delivery in peritoneal ovarian cancer.
- To investigate the drug loading, release kinetics, and stability of cisplatin-loaded mesoporous silica nanoparticles (MSNs).
- To assess the efficacy, pharmacokinetics, and biodistribution of modified MSNs compared to free cisplatin.
Main Methods:
- Synthesis of cisplatin-loaded dendritic mesoporous silica nanoparticles (Pt-MSNs) and poly-(acrylic acid)-modified versions (Pt-PAA-MSNs).
- In vitro characterization of particle stability, size, shape, and drug release profiles.
- Evaluation of anticancer efficacy (IC50), pharmacokinetic (PK) studies, and biodistribution analysis in a metastasis mouse model.
Main Results:
- Stable, uniform nanoparticles (Pt-MSNs and Pt-PAA-MSNs) were achieved with high drug loading (up to 18%).
- Pt-PAA-MSNs demonstrated sustained cisplatin release, accelerated in acidic tumor environments, and a 4.8-fold improvement in IC50.
- Pharmacokinetic studies showed significantly increased peritoneal retention and reduced systemic absorption of cisplatin with Pt-PAA-MSNs.
- Biodistribution studies confirmed enhanced cisplatin accumulation in peritoneal tumors following MSN administration.
Conclusions:
- Poly-(acrylic acid)-modified dendritic mesoporous silica nanoparticles (Pt-PAA-MSNs) represent a promising platform for ovarian cancer peritoneal metastasis.
- These nanoparticles improve cisplatin retention in the peritoneal cavity and enhance its anti-tumor efficacy.
- The pH-sensitive nature of PAA further optimizes drug release in the tumor microenvironment, suggesting potential for improved clinical outcomes.
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