Related Experiment Video
Updated: Feb 4, 2026
12:10
Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
9.3K
Prognostic Factors of Castration-Resistant Prostate Cancer Among Patients With Localized Prostate Cancer Who
Takeshi Sasaki1, Atsushi Igarashi2, Shin Ebara3
1Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Summary
Biopsy grade group 5, lymphovascular invasion, and persistent PSA levels are key predictors for developing castration-resistant prostate cancer (CRPC) after robot-assisted radical prostatectomy (RARP). These factors help stratify patient risk effectively.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Robot-assisted radical prostatectomy (RARP) is a common treatment for prostate cancer (PCa).
- Identifying risk factors for castration-resistant prostate cancer (CRPC) post-RARP is crucial for patient management.
Purpose of the Study:
- To identify clinicopathological risk factors for CRPC development in patients treated with RARP.
- To establish a predictive model for CRPC risk stratification.
Main Methods:
- Retrospective analysis of 2825 PCa patients from nine Japanese institutions (2012-2021).
- Exclusion of patients with metastatic disease or neoadjuvant/adjuvant therapy.
- Definition of persistent prostate-specific antigen (PSA) as ≥0.2 ng/mL postoperatively.
Main Results:
- 17.4% experienced biochemical recurrence, 0.8% developed CRPC.
- Multivariate analysis identified biopsy grade group 5 (aHR 12.74), lymphovascular invasion (aHR 3.90), and persistent PSA (aHR 8.66) as independent predictors of CRPC.
- A model using these three factors effectively stratified CRPC-free survival.
Conclusions:
- Biopsy grade group 5, lymphovascular invasion, and persistent PSA levels are significant independent predictors of CRPC.
- This combination of factors can stratify CRPC risk in patients undergoing RARP.
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