Combining search filters for randomized controlled trials with the Cochrane RCT Classifier in Covidence: a...

Our objective was to evaluate the recall and number needed to read (NNR) for the Cochrane RCT Classifier compared to and in combination with established search filters developed for Ovid MEDLINE and Embase.com. A gold standard set of 1,103 randomized controlled trials (RCTs) was created to calculate recall for the Cochrane RCT Classifier in Covidence, the Cochrane sensitivity-maximizing RCT filter in Ovid MEDLINE and the Cochrane Embase RCT filter for Embase.com. In addition, the classifier and the filters were validated in three case studies using reports from the Swedish Agency for Health Technology Assessment and Assessment of Social Services to assess impact on search results and NNR. The Cochrane RCT Classifier had the highest recall with 99.64% followed by the Cochrane sensitivity-maximizing RCT filter in Ovid MEDLINE with 98.73% and the Cochrane Embase RCT filter with 98.46%. However, the Cochrane RCT Classifier had a higher NNR than the RCT filters in all case studies. Combining the RCT filters with the Cochrane RCT Classifier reduced NNR compared to using the RCT filters alone while achieving a recall of 98.46% for the Ovid MEDLINE/RCT Classifier combination and 98.28% for the Embase/RCT Classifier combination. In conclusion, we found that the Cochrane RCT Classifier in Covidence has a higher recall than established search filters but also a higher NNR. Thus, using the Cochrane RCT Classifier instead of current state-of-the-art RCT filters would lead to an increased workload in the screening process. A viable option with a lower NNR than RCT filters, at the cost of a slight decrease in recall, is to combine the Cochrane RCT Classifier with RCT filters in database searches.