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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
Published on: December 5, 2017
Prognostic Significance of Different Ki-67 Cutoff Values Defined Luminal B HER2-Negative Breast Cancer
Xin Ye1,2,3, Xiaoyun Zhou1,2,3, Qi He1,2,3
1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
None:
Luminal B (HER2-) breast cancer is defined as ER- or PR-positive and HER2-negative meeting with PR ≤ 20%, or ER- or PR-positive and HER2-negative with high Ki-67 index, which has worse prognoses. The locally specified Ki-67 cutoff value has remained elusive in China. 4940 patients with ER- or PR-positive and HER2-negative operable breast cancer were recruited. The novel findings was that luminal B (HER2-) tumors showed poor DFS regardless of Ki-67 cutoff values (14, 20 or 30%), and luminal B (HER2-) subtype(PR ≤ 20% and high Ki-67 index) tumors showed inferior OS, DMFS, and BCSS. With Ki-67 cutoff value of 20%, it was optimized to distinguish prognostic differences.
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