Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...

Kidney Structure

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

Magnetic Declination

Magnetic Declination

Magnetic declination is the angle between true north, which aligns with the Earth's rotational axis, and magnetic north, which follows the direction of the Earth's magnetic field. This discrepancy exists because the magnetic poles do not coincide with the geographic poles. The value of magnetic declination depends on the observer's location on Earth and is subject to changes over time due to the dynamic nature of the Earth's magnetic field.The declination is called eastern when magnetic north...

Conservation of Declining Populations

Conservation of Declining Populations

Conservation of declining population focuses on ways of detecting, diagnosing, and halting a population decline. The approach uses methods to prevent populations from going extinct.

Functional Groups

Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...

Hormonal Regulation

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preclinical evaluation of a bioartificial kidney loaded with functional renal tubular cells in a Bama miniature pig model of acute renal failure.

Burns & trauma·2026

Same author

Urinary miR-142-3p: a novel biomarker of the progression of IgA nephropathy.

Frontiers in immunology·2026

Same author

Association between anti-nephrin autoantibodies and disease activity in minimal change disease.

Annals of medicine·2026

Same author

Hemoadsorption Combined with Hemodialysis (HAHD): a Consensus Statement from an International Expert Panel.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026

Same author

A machine learning model based on routine blood-derived indices for early arterial stiffness prediction in the community.

Lipids in health and disease·2026

Same author

Heterogeneity in the efficacy of bosentan for hypertensive nephropathy: a study on individualized benefit prediction models based on pathological subtyping and dynamic trajectories.

Annals of medicine·2026

Search research articles

Related Experiment Video

Updated: Feb 4, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Single-nephron eGFR and kidney function decline in IgA nephropathy.

Chen Yang^1,2, Shuang Liang², Zhi- Yu Duan²

¹School of Medicine, Nankai University, Tianjin, China.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|February 2, 2026

Summary

This summary is machine-generated.

Higher single-nephron estimated glomerular filtration rate (eGFR) is a risk factor for kidney function decline in IgA nephropathy (IgAN) patients. This finding suggests single-nephron eGFR can aid in early risk stratification for IgAN progression.

Keywords:

IgA nephropathy glomerular hyperfiltration prognosis risk stratification single-nephron eGFR

More Related Videos

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Feb 4, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

Area of Science:

Nephrology
Renal Physiology
Immunology

Background:

IgA nephropathy (IgAN) progression involves compensatory hyperfiltration by residual nephrons, potentially accelerating kidney function decline.
The prognostic value of single-nephron estimated glomerular filtration rate (eGFR) in IgAN is unclear due to measurement challenges.
This study investigates the impact of single-nephron eGFR on kidney function decline in IgAN patients.

Purpose of the Study:

To assess the prognostic value of single-nephron eGFR in predicting kidney function decline in IgA nephropathy (IgAN).
To determine if single-nephron eGFR can serve as an early risk-stratification tool for IgAN progression.

Main Methods:

An observational cohort study of 187 biopsy-confirmed IgAN patients.
Single-nephron eGFR estimated by dividing total eGFR by nephron number derived from CT scans and biopsy data.
Cox proportional hazards models used to analyze associations between single-nephron eGFR and kidney function decline (defined by eGFR decrease or ESRD).

Main Results:

Higher single-nephron eGFR was significantly associated with reduced kidney survival (log-rank P < 0.001).
Compared to the low single-nephron eGFR group, hazard ratios for kidney function decline were 2.50 (middle group) and 5.30 (high group).
57 out of 187 participants experienced kidney function decline over a median follow-up of 3.1 years.

Conclusions:

Elevated single-nephron eGFR is a risk factor for kidney function decline in IgAN patients.
Single-nephron eGFR shows potential as an early risk-stratification tool for IgAN.
Relying solely on eGFR cutoffs for hyperfiltration definition may lead to misclassification.