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Updated: Feb 4, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
[The new S3 guideline on schizophrenia (living) 2025]
Theresa Halms1, Wolfgang Gaebel2,3, Stefan Leucht4,5
1Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Medizinische Fakultät, Universität Augsburg, Geschwister-Schönert-Straße 1, 86156, Augsburg, Deutschland. Theresa.Halms@med.uni-augsburg.de.
Background:
On 15 October 2025, the revised S3 guideline on schizophrenia (living) was published and transferred to the MAGICapp evidence ecosystem and will be updated annually in the future.
Objective:
This narrative review summarizes essential innovations and explains their development.
Material And Methods:
New and revised recommendations and MAGICapp background information were extracted and summarized.
Results And Conclusion:
The guideline is now fully integrated into MAGICapp and annually updated. Key changes include a downgrading of the recommendation for antipsychotic monotherapy, a substantial expansion of guidance on adverse effect monitoring and management and a strengthened emphasis on evidence-based psychotherapeutic interventions, such as metacognitive training and systemic therapy. Additionally, 4 new recommendations (digital/technology-assisted interventions, mindfulness-based procedures, acceptance and commitment therapy [ACT], trauma-focussed therapy for post-traumatic stress disorder [PTSD]) were implemented and 12 were removed. All chapters were comprehensively revised.
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