Related Experiment Video

Updated: Jul 11, 2026

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
12:12

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Published on: February 8, 2016

Immunomodulatory effects and gut microbiota modulation by brewer's yeast mannatide in cyclophosphamide-induced

Shuang Zhao1, Haidi Wang1, Shuo Zhao1

  • 1College of Life Sciences , Qingdao University , Qingdao, 266071, China.

Archives of Microbiology
|February 2, 2026
PubMed

Insights

Mannatide (MTE) from brewer's yeast enhances immune function and gut health. This yeast-derived compound shows potential as a dietary supplement for both healthy and immunosuppressed individuals.

Area of Science:

  • Immunology
  • Microbiology
  • Nutrition Science

Background:

  • Yeast is integral to food production (brewing, baking).
  • Brewer's yeast contains bioactive compounds with potential health benefits.
  • Understanding yeast-derived compounds' immunomodulatory effects is crucial for health applications.

Purpose of the Study:

  • To investigate the immunomodulatory and prebiotic potential of mannatide (MTE) from brewer's yeast.
  • To assess MTE's effects in cyclophosphamide (CTX)-induced immunosuppressed mice.
  • To evaluate MTE's impact on gut microbiota and immune parameters in both healthy and immunosuppressed mice.

Main Methods:

  • Administration of MTE to CTX-induced immunosuppressed mice and untreated mice.
  • Assessment of body weight, organ morphology, and immune cytokines (TNF-α, IFN-γ).
  • Analysis of gut microbiota composition and expression of tight junction proteins (Occludin, E-cadherin, ZO-1).

Main Results:

  • MTE alleviated immunosuppression-induced body weight loss and restored organ morphology.
  • MTE increased key immune cytokines (TNF-α, IFN-γ) in immunosuppressed mice.
  • MTE normalized gut microbiota, enriched beneficial bacteria, and upregulated tight junction proteins.

Conclusions:

  • MTE demonstrates significant immunomodulatory effects in immunosuppressed mice.
  • MTE acts as a prebiotic, promoting beneficial gut bacteria in both healthy and immunosuppressed states.
  • MTE shows promise as a dietary supplement for enhancing immune health and gut function.
Keywords:
CyclophosphamideGut microbiotaImmunomodulatoryMannatideSpent brewer’s yeast

More Related Videos

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis06:39

Curcuminoid-Mediated Antimicrobial Photodynamic Therapy on a Murine Model of Oral Candidiasis

Published on: October 27, 2023

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...