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Cardiovascular adverse effects of common non-oncologic medications: from mechanisms to clinical management

M Cecilia Bahit1,2, Pilar Agudo-Quilez3, Jose Zamorano3

  • 1Baim Institute for Clinical Research, 930 Commonwealth Ave, Boston, MA 02215, USA.

European Heart Journal. Cardiovascular Pharmacotherapy
|February 2, 2026
PubMed

Insights

Many non-cancer drugs can cause serious cardiovascular adverse effects, including heart failure and arrhythmias. Understanding these drug risks is crucial for patient safety and effective cardiovascular practice.

Area of Science:

  • Pharmacology
  • Cardiology
  • Internal Medicine

Background:

  • Cardiovascular adverse effects are a significant concern in patient management.
  • While oncologic drugs are known culprits, non-oncologic medications also pose cardiovascular risks.
  • These risks encompass a spectrum of cardiac issues, including arrhythmias, heart failure, and cardiomyopathy.

Purpose of the Study:

  • To review common non-oncologic drugs causing cardiovascular adverse effects.
  • To elucidate the mechanisms underlying these drug-induced cardiovascular harms.
  • To highlight clinical manifestations and implications for cardiovascular practice.

Main Methods:

  • This is a narrative review.
  • Literature search on non-oncologic drugs and cardiovascular adverse events.
  • Focus on mechanisms, clinical presentation, and practical implications.

Main Results:

  • Non-oncologic drugs implicated include antibiotics, antidiabetics, NSAIDs, GI/urologic drugs, and cardiovascular agents.
  • Adverse effects range from QT prolongation and arrhythmias to myocardial infarction and cardiomyopathy.
  • Mechanisms vary depending on the drug class.

Conclusions:

  • Non-oncologic medications represent an underappreciated source of cardiovascular harm.
  • Awareness of these drug-induced effects is essential for clinicians.
  • Managing these risks requires a thorough understanding of drug mechanisms and patient history.
Keywords:
Cardiac safetyCardiotoxicityCardiovascular adverse effectsNon-oncologic drugs

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