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Updated: Feb 4, 2026

Porcine As a Training Module for Head and Neck Microvascular Reconstruction
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Driving progress in recurrent and metastatic head and neck cancer: the NRG Oncology perspective

Mercedes Herrera1, Matthew Ward2, Glenn J Hanna3

  • 1Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Journal of the National Cancer Institute
|February 2, 2026
PubMed

Insights

Advanced head and neck cancers pose treatment challenges. This paper identifies research gaps and proposes strategies for recurrent/metastatic squamous cell carcinoma, aiming to improve patient outcomes.

Area of Science:

  • Oncology
  • Immunotherapy
  • Clinical Trial Design

Background:

  • Head and neck cancers are diverse with varied prognoses.
  • Advanced-stage disease management remains challenging.
  • Immune checkpoint inhibitors offer new treatment avenues.

Purpose of the Study:

  • Identify clinical practice gaps in recurrent/metastatic head and neck cancer.
  • Identify scientific literature gaps.
  • Propose research recommendations for recurrent/metastatic squamous cell carcinoma of the head and neck.

Main Methods:

  • Critical review of current clinical practice.
  • Analysis of existing scientific literature.
  • Expert consensus from the NRG Oncology Recurrent/Metastatic Head and Neck Working Group.

Main Results:

  • Gaps in understanding tumor biology and treatment resistance identified.
  • Need for novel clinical trial designs highlighted.
  • Specific unmet needs in recurrent/metastatic squamous cell carcinoma outlined.

Conclusions:

  • Further innovation is crucial for managing advanced head and neck cancers.
  • A nuanced approach to clinical trial design is necessary.
  • Actionable recommendations are provided for future research directions.

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