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Two new abietane diterpenoids from Salvia cavaleriei var. simplicifolia
Qian Wu1, Jie Yang1, Mi-Na Yang1
1School of Pharmacy and State Key Laboratory of Natural Product Chemistry, Lanzhou University, Lanzhou, P. R. China.
Abstract:
A phytochemical investigation of the ethanol extract of Salvia cavaleriei var. simplicifolia E.Peter yielded two new abietane-type diterpenoids, salcasins C and D (1 and 2), along with six known diterpenoids (3-8). The chemical structures and absolute configurations of these isolates were unambiguously determined using comprehensive spectroscopic methods, coupled with DP4+ analysis and electronic circular dichroism (ECD) calculations. Additionally, the in vivo anti-Alzheimer's disease (AD) activity of all isolates (1-8) was assessed using a transgenic Caenorhabditis elegans AD pathological model. However, at a concentration of 100 μM, none of the tested compounds demonstrated anti-AD activity.
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