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Allergen-Specific Immunoglobulin E Distribution and Correlations in Pediatric Patients: A Retrospective Study in

Ming-Yi Ye1, Meng-Jie Xu1, Jun-Jie Chen1

  • 1Department of Pediatrics, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.

International Archives of Allergy and Immunology
|February 2, 2026
PubMed

Insights

Pediatric respiratory allergies in Guangzhou show age-specific allergen profiles. Infants and toddlers are more prone to food allergens, while older children react more to inhalant allergens like dust mites.

Area of Science:

  • Pediatric Allergy and Immunology
  • Environmental Health
  • Epidemiology

Background:

  • Respiratory allergic diseases pose a significant health burden in children.
  • Understanding regional allergen profiles is crucial for effective management.
  • Guangzhou, China, presents a unique demographic for studying pediatric allergies.

Purpose of the Study:

  • To analyze allergen profiles in children with respiratory allergies in Guangzhou.
  • To identify age-specific sensitization patterns.
  • To inform prevention and management strategies for pediatric allergic diseases.

Main Methods:

  • A cross-sectional study involving 1,230 children (0-14 years) in Guangzhou.
  • Allergen-specific immunoglobulin E antibody testing via immunoblotting.
  • Analysis of allergen positivity rates across age groups, seasons, sex, and allergen types.

Main Results:

  • 43.9% of children showed sensitization to at least one allergen.
  • Predominant inhalant allergen: Dermatophagoides farinae/pteronyssinus (22.93%).
  • Most common food allergen: egg white/yolk (10.73%).
  • Food allergens were dominant in infants/toddlers; inhalant allergens in older children.

Conclusions:

  • Allergen sensitization patterns in Guangzhou children evolve with age.
  • Age-appropriate diagnostic and management strategies are essential.
  • Region-specific data supports tailored public health interventions for pediatric respiratory allergies.
Abstract

Keywords:
AllergensChildrenGuangdong ProvinceImmunoglobulin ERespiratory allergic diseases

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