Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nucleic Acids

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...

Nucleic acids

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...

Nucleic Acids

Nucleic Acids

Nucleic Acid Structure

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...

Nucleic Acids and Nucleotides

Nucleic Acids and Nucleotides

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....

Biosynthesis of Nucleic Acids

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Distinct neural processes link speech planning and execution.

bioRxiv : the preprint server for biology·2026

Same author

Observations from the RESET clinical trial: A post-hoc per protocol analysis of clinical outcomes with percutaneous 60-day medial branch PNS in chronic low back pain.

Interventional pain medicine·2026

Same author

General-purpose large language models outperform specialized clinical AI tools on medical benchmarks.

Nature medicine·2026

Same author

Asking Big Questions in Neurosurgery.

Neurosurgery·2026

Same author

Effect of PEEP mask on cough in patients with tracheobronchomalacia.

BMC pulmonary medicine·2026

Same author

The American Society of Pain and Neuroscience (ASPN) Evidence-Based Consensus Recommendations on Programming and Coding Implantable Spinal Cord Stimulation Devices for Treatment of Chronic Intractable Pain.

Journal of pain research·2026

Search research articles

Related Experiment Video

Updated: Feb 4, 2026

In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions

In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions

Published on: July 17, 2019

Large-scale multi-omic biosequence transformers for modeling protein-nucleic acid interactions.

Sully F Chen¹, Robert J Steele², Glen M Hocky³

¹Duke University School of Medicine, Department of Neurosurgery, Durham, North Carolina, United States of America.

|February 2, 2026

Summary

OmniBioTE, a novel multi-omic model, integrates protein and nucleic acid data for enhanced biological sequence understanding. This approach achieves state-of-the-art predictions for biomolecular interactions and reveals emergent structural insights.

More Related Videos

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

Electricity-Free, Sequential Nucleic Acid and Protein Isolation

Electricity-Free, Sequential Nucleic Acid and Protein Isolation

Published on: May 15, 2012

Related Experiment Videos

Last Updated: Feb 4, 2026

In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions

In Vitro Biochemical Assays using Biotin Labels to Study Protein-Nucleic Acid Interactions

Published on: July 17, 2019

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

Electricity-Free, Sequential Nucleic Acid and Protein Isolation

Electricity-Free, Sequential Nucleic Acid and Protein Isolation

Published on: May 15, 2012

Area of Science:

Bioinformatics
Computational Biology
Molecular Biology

Background:

Transformer models have advanced bioinformatics, excelling in single-omic tasks like protein structure prediction.
Current models trained on single data types (proteins or nucleic acids) struggle to capture cross-modal biological interactions.

Purpose of the Study:

Introduce OmniBioTE, the largest open-source multi-omic foundation model for biological sequences.
To demonstrate the capability of multi-omic training for capturing gene-protein relationships and interaction properties.

Main Methods:

Trained OmniBioTE on over 250 billion tokens of mixed protein and nucleic acid sequence data.
Evaluated OmniBioTE's performance on predicting binding free energy and identifying protein residues involved in interactions.

Main Results:

OmniBioTE learns joint representations mapping genes to protein sequences from unlabeled data.
Achieved state-of-the-art results in predicting binding free energy for protein-nucleic acid interactions.
Demonstrated emergent learning of structural information and superior performance-per-FLOP compared to single-omic models.

Conclusions:

Multi-omic transformer models offer a unified approach for biological sequence analysis.
OmniBioTE serves as a powerful foundation model for advancing multi-omic biological discovery and understanding.