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Related Experiment Video

Updated: Feb 4, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Spondylodiscitis: A False-Positive Pitfall in 68 Ga-PSMA Scintigraphy.

Amin Saber Tanha¹, Farid Jafari Zarrin Ghabaei¹, Hamidreza Ghorbani^2,3

¹Nuclear Medicine Research Center, Mashhad University of Medical Sciences.

Clinical Nuclear Medicine

|February 2, 2026

Summary

Prostate-specific membrane antigen (PSMA) imaging can show false positives. Spondylodiscitis mimicked prostate cancer spread on PSMA scans, highlighting the need for clinical correlation to avoid misdiagnosis.

Keywords:

PRIMARY score mpMRI pitfall prostate cancer staging

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Area of Science:

Nuclear Medicine
Radiology
Oncology

Background:

Elevated prostate-specific antigen (PSA) and urinary symptoms can indicate prostate cancer.
Gallium-68 (68Ga) PSMA scintigraphy is a key imaging modality for prostate cancer staging.
Distinguishing true disease from artifact or benign conditions is crucial for accurate diagnosis.

Purpose of the Study:

To assess the diagnostic utility of 68Ga-PSMA scintigraphy in a patient with suspected prostate cancer.
To investigate the potential for false-positive findings on PSMA imaging.
To emphasize the importance of integrating imaging with clinical and laboratory data.

Main Methods:

A 65-year-old male patient with elevated PSA and urinary symptoms underwent 68Ga-PSMA PET/CT.
Clinical history, inflammatory markers, and CT findings were correlated with PSMA uptake patterns.
PRIMARY score was assessed based on PSMA uptake distribution.

Main Results:

The scan revealed increased PSMA uptake in vertebral endplates, consistent with spondylodiscitis.
Symmetrical PSMA uptake in the prostate was observed, correlating with a PRIMARY score of 2.
Spondylodiscitis was confirmed through clinical and laboratory data.

Conclusions:

Spondylodiscitis can present as a false-positive finding on 68Ga-PSMA scintigraphy.
Accurate interpretation of PSMA PET/CT requires correlation with clinical presentation and laboratory markers.
Careful evaluation is essential to prevent misdiagnosis of prostate cancer progression.