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Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
Theranostic Folate-Targeted Doxorubicin-Loaded MIL-88A@CuFe2O4 Nanohybrids, a pH-Sensitive, Core-Shell, Mesoporous
Motahareh Rezvan1,2, Amirhosein Kefayat3,4, Mohammadmahdi Doostmohammadi1
1Medical Nanotechnology Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran 1517964311, Iran.
We developed a novel MIL-88A@CuFe2O4 nanohybrid for cancer theranostics. This platform integrates dual-mode MRI and optical imaging with targeted drug delivery for precise cancer diagnosis and treatment.
Area of Science:
- Materials Science and Nanotechnology
- Biomedical Engineering
- Radiology and Medical Imaging
Background:
- Multifunctional nanoplatforms are crucial for precision cancer management, integrating imaging and therapy.
- Existing theranostic agents face limitations in combining imaging modalities, targeted delivery, and therapeutic efficacy.
- Developing smart nanohybrids with strong magnetic properties and versatile theranostic capabilities is essential.
Purpose of the Study:
- To report the theranostic application of a novel in situ mesoporous core-shell MIL-88A@CuFe2O4 nanohybrid.
- To evaluate its potential as a smart platform for dual-mode MRI and optical imaging with quantitative analysis.
- To assess its pH-sensitive targeted drug delivery capabilities and therapeutic efficacy in cancer models.
Main Methods:
- Fabrication of MIL-88A@CuFe2O4 nanohybrids via in situ synthesis using CuFe2O4 core and Fe3+ source for MIL-88A shell.
- Characterization of nanohybrid structure, porosity, and magnetic properties.
- Evaluation of dual-mode T1-T2 MRI contrast enhancement, pH-sensitive doxorubicin release, folate-mediated active tumor targeting, and in vitro/in vivo biocompatibility and efficacy.
Main Results:
- Successful synthesis of mesoporous MIL-88A@CuFe2O4 nanohybrids with high porosity and strong magnetism.
- Achieved robust dual-mode MRI contrast (T1 and T2) with high relaxivity values (r1 = 73.0 mM−1 s−1, r2 = 700.9 mM−1 s−1).
- Demonstrated pH-sensitive drug release, selective cancer cell uptake, effective tumor targeting, and significant tumor growth inhibition in a 4T1 mouse model.
Conclusions:
- The MIL-88A@CuFe2O4 nanohybrid serves as a unique multifunctional platform for precise cancer diagnosis and treatment.
- Its combination of high porosity, strong magnetism, dual T1-T2 MRI contrast, and targeted drug delivery offers significant advantages over existing theranostic agents.
- This study highlights the potential of MIL-88A@CuFe2O4 nanohybrids for advanced cancer theranostics.
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