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Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Published on: May 5, 2011

Adaptive support ventilation with IntelliSync versus pressure support ventilation for non-invasive ventilation in

Selva Vijay¹, Inderpaul Singh Sehgal¹, Ritesh Agarwal¹

¹Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Respiratory Medicine

|February 2, 2026

Abstract

Background:

While non-invasive ventilation (NIV) is recommended for managing acute exacerbations of chronic obstructive pulmonary disease (AECOPD), it has a 30-40% failure rate when delivered using pressure support ventilation (PSV). Adaptive support ventilation with IntelliSync (ASVi) synchronizes breath initiation and cycling to match patient's requirements. We conducted a feasibility study to inform design of a larger trial and compared NIV failure rates using PSV or ASVi in patients with AECOPD.

Materials And Methods:

We conducted a single-center, randomized controlled trial from December 2023 to April 2025 in subjects with AECOPD. Subjects were randomized (1:1) to receive NIV using PSV or ASVi. The primary outcome was NIV failure, defined as the need for airway intubation. Key secondary outcomes included the asynchrony index and 28-day all-cause mortality.

Results:

We included 55 consecutive subjects with AECOPD (ASVi, n = 26; PSV, n = 29), with a mean age of 63 years. NIV failure occurred in15.4% (4/26) with ASVi versus 31% (9/29) with PSV, representing a 50% relative risk reduction (absolute difference 15.6%, 95% CI: -6.2%-37.5%, P = 0.17). Asynchrony index was similar between groups (22.6 ± 17.8 ASVi vs. 21.5 ± 16.7 PSV, P = 0.83). ASVi was associated with significantly greater patient comfort (P = 0.048) and shorter hospital stay (3.9 ± 2.9 vs 5.8 ± 4.0 days, P = 0.021).

Conclusion:

This study demonstrates that ASVi is safe, feasible to implement, and associated with improved patient comfort and significantly reduced hospital stay in AECOPD. The observed 50% relative reduction in NIV failure rates, although not statistically significant, represents a clinically meaningful effect that warrants evaluation in a larger trial.

Keywords:

ASV Airway intubation Artificial airway Respiratory failure Ventilation

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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

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