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Antigen Processing Pathways01:31

Antigen Processing Pathways

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
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Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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C4 Pathway and CAM01:27

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Feb 4, 2026

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

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Mechanistic insights into stem cell aging: Pathways and processes.

Ayesha Fauzi1, Chloe Zi En Wong2, Phoebe Yon Ern Tee3

  • 1School of Biosciences, Faculty of Health & Medical Sciences, Taylor's University, Selangor, Malaysia; Centre for Active Living (CAL), Taylor's University, Selangor, Malaysia.

Mechanisms of Ageing and Development
|February 2, 2026
PubMed
Summary
This summary is machine-generated.

Aging impairs stem cell function through cellular stress, epigenetic changes, and metabolic issues. Understanding these mechanisms is key to preserving tissue regeneration and health in aging populations.

Keywords:
AgingDNA methylationEpigenetic dysregulationSenescenceStem cell

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Area of Science:

  • Gerontology
  • Stem Cell Biology
  • Molecular Biology

Background:

  • Aging progressively impairs stem cell function, affecting tissue homeostasis and increasing age-related diseases.
  • Stem cell aging is a critical factor in reduced regenerative capacity and overall health decline.

Purpose of the Study:

  • To synthesize current evidence on the molecular and cellular mechanisms driving stem cell aging.
  • To provide a framework for identifying targets to preserve stem cell function in aging tissues.

Main Methods:

  • Review of current scientific literature on stem cell aging.
  • Integration of evidence on cellular stress, epigenetics, telomere dynamics, metabolism, and signaling pathways.

Main Results:

  • Accumulation of cellular stress (oxidative, genotoxic, ER) disrupts genomic stability and proteostasis.
  • Epigenetic alterations destabilize transcriptional programs essential for stem cell identity and function.
  • Telomere shortening, metabolic dysregulation (mTOR, AMPK), and altered signaling pathways contribute to stem cell dysfunction and senescence.

Conclusions:

  • Multiple interconnected molecular and cellular mechanisms drive stem cell aging.
  • These aging processes impair stem cell maintenance, differentiation, and regenerative output.
  • Identifying regulatory targets is crucial for interventions aimed at preserving stem cell function and tissue health during aging.