Related Experiment Video
Updated: Feb 4, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Antidiabetic effects of Agaricus bisporus polysaccharide in HFD/STZ-induced mice
Ziyang Wang1, Qinqin Ouyang1, Haiying Guo1
1Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing, 100083, China.
Abstract:
Fungal polysaccharides have garnered attention for their antidiabetic potential. Here, we evaluated five edible fungal polysaccharides-Agaricus bisporus (ABP), Pleurotus eryngii (PEP), Boletus spp. (BP), Lentinus edodes (LEP), and Pleurotus ostreatus (POP) in type 2 diabetic mice. All alleviated diabetic symptoms to varying degrees, with ABP showing the most pronounced effects. ABP improved body weight, reduced hyperphagia and polydipsia, lowered fasting glucose, and enhanced glucose tolerance and insulin sensitivity. Histological analysis showed that ABP better preserved pancreatic islets and reduced hepatic steatosis and inflammation. Mechanistically, ABP activated insulin signaling (IRS1/PI3K/Akt) and energy-sensing (AMPK) pathways. Liver metabolomics further revealed that ABP most effectively reversed diabetes-related metabolic disturbances. These findings suggest that ABP has the strongest antidiabetic activity among the five polysaccharides tested and holds considerable potential as a naturally derived intervention for managing T2DM.
Related Concept Videos
Biosynthesis of Polysaccharides
Cellulose and Pectic Polysaccharides
As a cell matures, its cell wall specializes according to its type. For example, the...
Biological Effects of Radiation
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
Framing Effects
Effects of feedback
Feedback significantly modifies the gain of a control system. The gain of a system without feedback is altered by a factor of one plus GH, where G represents...

