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Related Concept Videos

Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

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Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
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Inductance: Single-Phase And Three-Phase Line01:28

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Understanding the inductance of transmission lines is crucial for efficient design and operation in electrical power systems. This discussion delves into the inductance characteristics of single-phase two-wire and three-phase three-wire transmission lines with equal phase spacing.
Single-Phase Two-Wire Line:
A single-phase line consists of two solid cylindrical conductors, denoted as x and y. Each conductor carries phasor currents ix and iy, respectively. Given that the sum of these currents is...
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Capacitance: Single-Phase And Three-Phase Line01:25

Capacitance: Single-Phase And Three-Phase Line

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In electrical power systems, understanding the capacitance of transmission lines is fundamental for efficient operation.
Single-Phase Lines
Consider a single-phase, two-wire transmission line with equal phase spacing energized by a voltage source. One conductor carries a uniform positive charge, while the other carries an equal negative charge. The capacitance C of the line can be derived from the voltage V between the conductors. For a one-meter section of the line, the capacitance is given...
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Power Distribution in Three-phase and Single Phase Circuits01:17

Power Distribution in Three-phase and Single Phase Circuits

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Power distribution within electrical circuits is a foundational aspect of residential and industrial energy systems. While single-phase power is common in residential settings, three-phase power is the standard for industrial environments with heavy machinery. Each system is different and has advantages, and it's crucial to understand the underlying principles of power distribution and material efficiency.
Single-Phase Power Distribution:
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Muscles that Move the Arm01:31

Muscles that Move the Arm

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Nine muscles are involved in arm movements. Two of these, the pectoralis major and latissimus dorsi, originate from the axial skeleton and are called axial muscles. The other seven originate from the scapula and are called the scapular muscles.
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Lung Capacity01:47

Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Shortened High-dose Palliative Radiotherapy for Lung Cancer (SHiP-Rt): protocol for a single-arm, multicentre, phase

Raj Kumar Shrimali1, Ellanna Griffin2, Vicky Sturgess3

  • 1Institute for Precision Diagnostic & Translational Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

BMJ Open
|February 2, 2026
PubMed
Summary
This summary is machine-generated.

This study evaluates a new, shorter palliative radiotherapy (RT) schedule for non-small cell lung cancer (NSCLC) using modern techniques. The aim is to assess the safety and feasibility of this accelerated RT regimen.

Keywords:
Lung NeoplasmsRADIOTHERAPYRadiation oncologyRespiratory tract tumours

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Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Clinical Trials

Background:

  • Advanced non-small cell lung cancer (NSCLC) survival has improved with systemic therapy.
  • Current palliative radiotherapy (RT) protocols are based on outdated 1990s technology.
  • Contemporary RT utilizes advanced techniques like 4D-CT and VMAT for precision and reduced toxicity.

Purpose of the Study:

  • To evaluate the safety and feasibility of a shortened high-dose palliative RT regimen for NSCLC.
  • To assess a new dose-fractionation schedule using contemporary RT planning and delivery.
  • To explore potential benefits including toxicity profiles and cost-savings.

Main Methods:

  • A single-arm, multicentre, phase-II study recruiting 37 patients with advanced NSCLC.
  • Implementing a hypofractionated accelerated palliative RT regimen: 30 Gy in 6 alternate-day fractions.
  • Utilizing strict normal tissue dose constraints and quality assurance supported by RTTQA.

Main Results:

  • Primary objective: assess the safety of the proposed dose-fractionation.
  • Secondary objectives: evaluate toxicity, patient-reported outcomes, time to progression, feasibility, and NHS cost-saving.
  • Study registration: NCT06483308.

Conclusions:

  • The study aims to establish the safety and feasibility of an accelerated palliative RT schedule for NSCLC.
  • Findings will inform a potential phase III randomized controlled trial to assess efficacy.
  • Results will be disseminated to participants and published in a peer-reviewed journal.