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Updated: Feb 4, 2026

Isolation and Culture of Pulmonary Endothelial Cells from Neonatal Mice
Published on: December 14, 2010
[Role and research progress of vascular endothelial cells in pulmonary fibrosis]
Abstract:
Pulmonary fibrosis is an intractable lung disease characterized by scar tissue formation in pulmonary tissues and progressive respiratory failure. Recent research has increasingly highlighted the pivotal role of vascular endothelial cells in the initiation and progression of pulmonary fibrosis. Consequently, this review synthesizes current advances in elucidating vascular dysfunction, endothelial cell heterogeneity, and the associated molecular mechanisms underlying pulmonary fibrosis. Furthermore, it introduces the latest clinical research progress in targeting endothelial cells for therapeutic intervention against pulmonary fibrosis.
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