[Low-Temperature Dialysis: Is There Still a Rationale? A Summary of the Evidence from the Last Decade]

Hemodialysis performed with a low-temperature dialysate (< 36 °C) represents an effective strategy for preventing intradialytic hypotension and, more generally, for improving patient hemodynamics. Additional benefits from this approach may also extend to other systems, such as the cardiovascular and central nervous systems. Despite these undoubtedly favorable effects, some drawbacks have been reported, including significant patient discomfort, while data regarding extracorporeal clearance remain inconsistent. In light of these considerations, and through the analysis of major studies published in PubMed® over the past decade, we aim to provide a comprehensive and critical appraisal referred to as «cool dialysis».