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Perspectives on Neuroscience
Published on: July 31, 2007
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Microbiota in cancer: current understandings and future perspectives
Yanxi Yao1,2,3,4, Yifei Zhu1,2,3,4, Keji Chen1,2,3,4
1Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
Signal Transduction and Targeted Therapy
|February 2, 2026
Summary
The gut microbiota significantly influences cancer development and treatment response. Understanding these complex interactions is key to developing novel microbiota-targeted cancer therapies.
Area of Science:
- Oncology
- Microbiology
- Immunology
Background:
- The relationship between the microbiota and cancer is a rapidly growing research area.
- The microbiota plays critical roles in cancer development, progression, and patient outcomes.
- Understanding the microbiota's impact on cancer is crucial for developing new therapeutic strategies.
Purpose of the Study:
- To provide a historical overview of microbiota-cancer research.
- To explore the molecular mechanisms of microbiota-mediated cancer progression.
- To review current and emerging microbiota-targeted cancer therapies.
Main Methods:
- Literature review of historical and current microbiota-cancer studies.
- Analysis of molecular mechanisms involving oncogenic pathways, immune responses, and tumor metabolism.
- Examination of therapeutic strategies including probiotics, antibiotics, and fecal microbiota transplantation.
Main Results:
- The microbiota has dual roles in cancer, potentially promoting or inhibiting tumor growth.
- Microbiota composition influences responses to immunotherapy, chemotherapy, and radiotherapy.
- Emerging strategies like fecal microbiota transplantation show therapeutic promise.
Conclusions:
- Personalized approaches are needed to harness the microbiota's anticancer potential.
- This review offers a framework for advancing microbiota-targeted oncology research and clinical applications.
- Further research is essential to fully elucidate and utilize the microbiota's role in cancer treatment.
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