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Related Experiment Video

Updated: Feb 4, 2026

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Author Spotlight: Evaluating the Impact of Immediate Partial Removal of Cumulus-Oocyte Complexes on Fertilization Efficiency and Embryo Quality

Published on: October 18, 2024

Cumulus cell-mediated sperm selection enhances blastocyst quality using sibling oocytes.

Jorge Ten^1,2, Nerea Díaz³, Miguel Herreros³

¹Embryology Unit, Instituto Bernabeu, Alicante, Spain. jten@institutobernabeu.com.

Journal of Assisted Reproduction and Genetics

|February 2, 2026

Summary

Cumulus cell-mediated sperm selection significantly improved embryo quality in intracytoplasmic sperm injection (ICSI) cycles, especially for women aged 40-45. This method enhances blastocyst quality, potentially benefiting specific assisted reproductive technology (ART) populations.

Keywords:

Cumulus cells Embryo quality ICSI Sperm selection

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Meiotic Spindle Assessment in Mouse Oocytes by siRNA-mediated Silencing

Meiotic Spindle Assessment in Mouse Oocytes by siRNA-mediated Silencing

Published on: October 11, 2015

Area of Science:

Reproductive Medicine
Embryology
Assisted Reproductive Technology (ART)

Background:

Conventional sperm preparation methods may not always select the most viable sperm.
Cumulus cells play a role in natural sperm selection, a process not fully utilized in standard ICSI procedures.

Purpose of the Study:

To investigate if sperm selection via cumulus cells improves embryo quality compared to conventional density gradient centrifugation (DGC).
To determine if parental age influences the effectiveness of cumulus cell-mediated sperm selection.

Main Methods:

A prospective clinical trial involving 99 ICSI cycles.
Sibling oocytes were randomly assigned to either cumulus cell-mediated sperm selection or conventional DGC.
Embryo quality was assessed at the blastocyst stage on day 5.
Subanalysis examined the impact of parental age on outcomes.

Main Results:

The cumulus cell-mediated selection group had a significantly higher proportion of good-quality day-5 blastocysts (55.2% vs. 45.3%).
Significant improvement in blastocyst quality was observed in women aged 40-45.
Trends suggested improved outcomes in men aged 40-53, though not statistically significant.

Conclusions:

Cumulus cell-mediated sperm selection using a specialized ICSI dish increases the proportion of good-quality day-5 blastocysts.
This method shows potential benefits for specific ART subpopulations, particularly women of advanced maternal age.
Further research is needed to confirm these findings and their impact on clinical pregnancy rates.