Related Experiment Video
Updated: Feb 4, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Plasma Exchange for Anti-GBM Disease With Dialysis Dependency: A Case Series on Clinical Outcomes and Safety
Minoru Sakuragi1,2, Miho Miyauchi1,3, Misaki Kubo1,4
1Department of Nephrology and Dialysis, Medical Research Institute Kitano Hospital, PIIF Tazuke-Kofukai, Osaka, Japan.
Introduction:
The efficacy of plasma exchange (PEx) in patients with anti-glomerular basement membrane antibody (anti-GBM Ab) disease requiring renal replacement therapy (RRT) at diagnosis remains unclear. This study aimed to investigate the outcomes and safety of patients with uremic anti-GBM Ab disease undergoing PEx.
Methods:
We retrospectively analyzed nine patients confirmed by renal biopsy who received PEx using fresh frozen plasma or 5% human albumin solution and underwent hemodialysis (HD) concomitantly with standard immunosuppressive therapy. The outcome was determined as dialysis dependency, and safety was evaluated for adverse events.
Results:
Two patients (22.2%) achieved dialysis independence at 10 and 11 months. Both patients had relatively preserved normal glomeruli (15.8%-37.2%) and achieved early remission. Retroperitoneal hemorrhage and recalcitrant anti-GBM Ab were noteworthy in other cases.
Conclusion:
PEx can facilitate renal recovery in selected patients with anti-GBM disease requiring RRT. Pathological evaluation may be useful to determine the intensity and duration of treatment, including PEx.
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