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Updated: Feb 4, 2026

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Coagulation factor V as a novel regulator of tumor immunity in melanoma

Zhi Wang1,2, Hui Shi1,2, Mengmeng Zhuang3,4

  • 1Department of Dermatology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.

World Journal of Surgical Oncology
|February 3, 2026
PubMed
Abstract

Insights

Coagulation Factor V (F5) plays a key role in melanoma, impacting prognosis and immune response. Lower F5 expression correlates with worse outcomes, while its overexpression inhibits tumor growth and boosts immune chemokines.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Melanoma treatment advances rely on identifying molecular targets for precision therapies.
  • Coagulation Factor V (F5) is explored for its potential multifaceted role in melanoma.

Purpose of the Study:

  • To investigate the prognostic significance of Coagulation Factor V (F5) in melanoma.
  • To elucidate the impact of F5 on melanoma cell behavior and the tumor immune microenvironment.

Main Methods:

  • Utilized The Cancer Genome Atlas (TCGA) database for melanoma gene expression, clinical, and immune infiltration data.
  • Conducted in vitro experiments using the A2058 melanoma cell line to assess F5 function.

Main Results:

  • Significantly lower F5 expression in melanoma patients correlated with poorer prognosis.
  • F5 expression is strongly associated with immune cell populations and chemokines.
  • Overexpression of F5 in A2058 cells inhibited migration, proliferation, and colony formation, while increasing immune chemokine expression.

Conclusions:

  • Coagulation Factor V (F5) exhibits a significant role beyond coagulation in melanoma.
  • F5 demonstrates potential as a modulator of tumor immunity and biology in melanoma.
Keywords:
BiomarkerF5Immune regulationMelanoma

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