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Updated: May 11, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
Published on: November 4, 2016
Comment on: Pasco ST Et Al. "Challenge-Specific Modulation of Responses to Adjuvant-Induced Innate Immune Memory"
1University Institute of Allied Health Science, Chandigarh University, Mohali, Punjab, India.
Abstract:
This schematic illustrates the role of endoplasmic reticulum (ER) stress and PERK inhibition in modulating pancreatic cancer cell fate. ER stress activates the PERK pathway, which contributes to tumor cell survival. Pharmacologic inhibition of PERK, as depicted, leads to two downstream effects: decreased cellular proliferation and increased apoptosis. The diagram highlights the therapeutic potential of PERK-targeting strategies in disrupting cancer cell growth and promoting programmed cell death.
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