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Customized birth weight percentiles for identification of SGA short statue

Corinna Melanie Held1, Andreas Krebs2, Dirk Manfred Olbertz3,4

  • 1Department of Pediatrics and Adolescent Medicine, Schwarzwald-Baar-Klinikum, Villingen-Schwenningen, Germany.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|February 3, 2026
PubMed

Insights

Customized percentiles identify more small for gestational age (SGA) infants but do not increase the diagnosis of persistent short stature (SGA-SS) requiring growth hormone therapy compared to conventional methods.

Area of Science:

  • Pediatrics
  • Neonatology
  • Endocrinology

Background:

  • 10-15% of small for gestational age (SGA) children develop persistent short stature (SGA-SS), potentially benefiting from growth hormone therapy.
  • Customized percentiles, incorporating maternal factors, may improve the identification of at-risk newborns.

Purpose of the Study:

  • To evaluate if customized birth weight percentiles impact the diagnosis of SGA-SS and subsequent therapy decisions.
  • To compare the frequency of SGA-SS diagnosis using conventional versus customized percentile definitions.

Main Methods:

  • Analysis of birth data from 1321 infants (gestational age ≥30 weeks) using conventional and customized birth weight percentiles.
  • Assessment of growth data at 2 and 4 years to identify persistent short stature (SGA-SS) in SGA infants.

Main Results:

  • Customized percentiles identified more SGA infants (11.9%) than conventional ones (9.8%).
  • Forty-one infants of high-weight mothers were exclusively identified by customized percentiles.
  • Persistent short stature (SGA-SS) diagnosis at 2-4 years showed minimal difference between the two percentile methods.

Conclusions:

  • Customized percentiles increase the classification of SGA infants based on birth weight.
  • These customized methods do not appear to identify more cases of postnatal growth failure (SGA-SS) than conventional approaches.
Abstract

Keywords:
customized percentilesmaternal heightmaternal weightshort staturesmall for gestational age

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