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Related Concept Videos

Exercise and Muscle Performance01:27

Exercise and Muscle Performance

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Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
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Lung Capacity

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The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Updated: Feb 4, 2026

Skeletal Muscle Neurovascular Coupling, Oxidative Capacity, and Microvascular Function with 'One Stop Shop' Near-infrared Spectroscopy
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Home-Based Exercise Improves Muscle Oxidative Capacity in Kidney Disease.

Gwénaëlle Begue1,2, Armin Ahmadi2, Christopher Mt Hayden3

  • 1Kinesiology Department, California State University, Sacramento, California, USA.

Kidney International Reports
|February 3, 2026
PubMed
Summary
This summary is machine-generated.

A 12-week home exercise program improved muscle endurance and oxidative capacity in adults with moderate-to-severe chronic kidney disease (CKD). This intervention is a feasible strategy to combat functional decline in CKD patients.

Keywords:
chronic kidney diseaseexercisein-vivo mitochondrial bioenergeticsmagnetic resonance spectroscopymuscle oxidative capacityphysical performance

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Area of Science:

  • Nephrology
  • Exercise Physiology
  • Biochemistry

Background:

  • Muscle impairment in chronic kidney disease (CKD) leads to reduced physical function, frailty, and increased mortality.
  • Nondialysis CKD patients often experience decreased muscle endurance and oxidative capacity.

Purpose of the Study:

  • To evaluate the efficacy of a 12-week home-based, video-supervised exercise program.
  • To assess the program's impact on muscle endurance and mitochondrial bioenergetics in moderate-to-severe nondialysis CKD patients.

Main Methods:

  • A randomized controlled trial involving 32 sedentary adults with CKD (eGFR < 60 ml/min per 1.73 m²).
  • Participants were randomized to a home exercise group (EX, n=23) or usual care (UC, n=9).
  • Primary outcome: muscle mitochondrial bioenergetics (kPCr); Secondary outcomes: 6-minute walk test (6MWT), cardiopulmonary exercise testing (CPET), body composition, and plasma cytokines.

Main Results:

  • The exercise group (EX) showed significant increases in kPCr, total work, and 6MWT distance compared to usual care (UC).
  • EX preserved fat-free mass and marginally decreased fat mass.
  • Interleukin-8 concentration differed significantly between groups, while other cytokines and work efficiency did not show significant changes.

Conclusions:

  • Home-based, video-supervised exercise is a feasible and effective intervention for improving muscle oxidative capacity and endurance in nondialysis CKD.
  • This exercise strategy can help mitigate functional decline in patients with moderate-to-severe CKD.