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Updated: Feb 4, 2026
Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
Published on: August 16, 2021
Association between genetics variants and clinical outcomes in patients with left ventricular assist device
Elizabeth Silver1, Kimberly N Hong1, Hao A Tran1
1Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA.
Background:
Left ventricular assist device (LVAD) implantation is a life-saving therapy for end-stage heart failure, but right ventricular failure (RVF) remains a major complication. Current RVF risk models are limited. We hypothesized that pathogenic/likely pathogenic (P/LP) variants increase intrinsic RV vulnerability and post-LVAD RVF risk.
Methods And Results:
In a single-center retrospective study of 136 adults undergoing LVAD implantation in 2018-2024, 87% were male, 65% non-White, and 68% had non-ischemic cardiomyopathy. Genetic testing was completed in 48 (35%), identifying P/LP variants in 19%. Patients with P/LP variants had higher early RVF rates (89% vs. 38% vs. 15%, p<0.01) and longer hospitalizations (84 vs. 31 vs. 24 days, p=0.02) than those with variants of uncertain significance or negative results. Outcomes did not differ by ischemic versus non-ischemic etiology.
Conclusions:
P/LP variants were associated with early RVF, suggesting that genetic testing may inform RVF risk stratification and perioperative management.
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