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Pregabalin Toxicity in Kidney Failure: A Medication Error With Neurological Consequences
Adam G Selway1,2, Shea Roffey2, Anthony F Brown1,2
1Faculty of Medicine, University of Queensland, Brisbane, AUS.
Cureus
|February 3, 2026
Summary
A medication error caused severe pregabalin toxicity in a dialysis-dependent patient. Hemodialysis effectively treated the toxicity, highlighting the need for careful medication review in kidney failure patients.
Area of Science:
- Pharmacology
- Nephrology
- Clinical Toxicology
Background:
- Pregabalin is a gabapentinoid medication commonly prescribed for neuropathic pain and seizures.
- Patients with kidney failure are at increased risk of drug accumulation and toxicity.
- Medication errors can lead to significant adverse events, especially in vulnerable populations.
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