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Updated: Feb 4, 2026
07:05
Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
22.0K
Nanohydroxyapatite and Bioactive Glass Composites in Bone Regeneration: A Systematic Review
Shrinit Babel1, Sunit Babel2, Syed R Peeran3
1Morsani College of Medicine, University of South Florida, Tampa, USA.
Cureus
|February 3, 2026
Summary
Nanohydroxyapatite and bioactive glass composites show great promise for bone regeneration, offering improved biocompatibility and mechanical strength over traditional methods. Further research is needed for clinical application of these advanced biomaterials.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Traditional bone grafts and implants present challenges like donor site morbidity and poor integration.
- Nanohydroxyapatite (nHA) is a synthetic alternative but suffers from brittleness and low fracture toughness.
- Bioactive glass nanoparticles offer complementary properties for enhanced bone regeneration scaffolds.
Purpose of the Study:
- To systematically review the literature on nanohydroxyapatite-bioactive glass composites (HAGNs) for bone regeneration.
- To analyze the biocompatibility, osteoconductivity, and mechanical properties of HAGNs.
- To identify limitations and future research directions for HAGN clinical translation.
Main Methods:
- Systematic review following PRISMA guidelines.
- Comprehensive database search (Jan 2000 - Feb 2024) using MeSH terms for hydroxyapatite, glass nanoparticles, and bone regeneration.
- Screening and selection of 15 eligible peer-reviewed studies.
Main Results:
- HAGNs demonstrate improved biocompatibility and osteoconductivity compared to nHA alone.
- Various fabrication and consolidation techniques were explored for nHA-based scaffolds.
- Key properties of nHA, like low crystallinity and nanoscale dimensions, are crucial for mimicking natural bone.
Conclusions:
- nHA-bioactive glass composites are promising biomaterials for bone tissue engineering.
- These composites offer a combination of biocompatibility, osteoconductivity, and mechanical strength.
- Further research is essential to overcome fabrication challenges and confirm long-term performance for clinical translation.
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