Related Experiment Video

Updated: Feb 4, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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CircRNA-regulated programmed cell death networks in cardiomyocytes: Molecular crosstalk and therapeutic translation

Wenhua Jiang1,2, Yuetong Li3, Zhenxiong Liu2

  • 1Department of Cardiovascular Medicine, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Non-Coding RNA Research
|February 3, 2026
PubMed

Insights

Circular RNAs (circRNAs) regulate programmed cell death (PCD) in cardiovascular diseases (CVDs). This review highlights circRNAs as potential diagnostic and therapeutic targets for heart conditions.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genetics

Background:

  • Cardiovascular diseases (CVDs) are a leading global health issue.
  • Programmed cell death (PCD) pathways are critical in myocardial injury.
  • Circular RNAs (circRNAs) are emerging regulators of cardiomyocyte fate.

Purpose of the Study:

  • To review the role of circRNAs in modulating PCD in CVDs.
  • To explore circRNA-based diagnostics and therapeutics for CVDs.
  • To discuss future clinical translation strategies for circRNA research.

Main Methods:

  • Literature review synthesizing current research on circRNAs and PCD in CVDs.
  • Analysis of circRNA mechanisms including molecular sponging, protein interactions, and epigenetic regulation.
  • Evaluation of diagnostic and therapeutic applications of circRNAs.

Main Results:

  • CircRNAs act as key regulators of multiple PCD pathways (ferroptosis, apoptosis, pyroptosis, autophagy, necroptosis) in the heart.
  • CircRNA expression patterns can be used for CVD stratification with high accuracy.
  • Protective circRNAs delivered via viral vectors show efficacy in preclinical models of myocardial infarction.
  • CRISPR-based editing and nanoplatforms show promise for circRNA-based therapies.

Conclusions:

  • CircRNA networks represent promising theranostic targets for CVDs.
  • Context-dependent circRNA functions and pathway crosstalk require further investigation.
  • Tissue-specific delivery remains a challenge for clinical translation of circRNA therapies.

Keywords:
BiomarkerCardiovascular diseasesCircRNAProgrammed cell deathTherapeutic potential

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