Related Experiment Video
Updated: Feb 5, 2026
Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Unleashing the Potential of Anti-CD45RB Antibodies in Transplantation
Yanling Zhang1, Nan Li2, Yachao Li3
1Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Background:
Organ transplantation faces challenges of chronic rejection and infection due to immunosuppression. Inducing long-term immune tolerance is a key goal, with anti-CD45RB antibody being a studied target for decades.
Methods:
This review examines its mechanisms-modulating T cells (e.g.promoting Tregs), B cells, and cytokines-and efficacy across transplantation models (e.g.pancreatic, cardiac, cutaneous), including combination therapies.
Conclusions:
Efficacy varies by model: monotherapy induced tolerance in certain islet transplants but not skin grafts. Combination with agents like anti-CD40L or rapamycin significantly prolonged graft survival (e.g.to 100% in heart transplants). Dosage, timing, and recipient immune status influence outcomes, with Treg involvement as a common mechanism.
Future Directions:
Further research should explore synergies with clinical immunosuppressants and mechanisms in large animal xenografts to advance clinical translation.
More Related Videos
08:49Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals
Published on: February 14, 2019
07:51Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
Published on: March 18, 2019
Related Concept Videos
01:10Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
00:52Potential Energy
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
01:09Potential Energy
03:02Standard Electrode Potentials
02:58Cell Potential and Free Energy
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
01:21The Resting Membrane Potential