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Trends in Chronic Ischemic Heart Disease-Related Mortality in Older Adults With Atrial Fibrillation (1999-2023): A

Muhammad Shaheer Bin Faheem1, Syed Tawassul Hassan2, Tehreem Asghar3

  • 1Department of Medicine and Surgery, Karachi Institute of Medical Sciences, KIMS, Karachi, Pakistan.

Clinical Cardiology
|February 3, 2026
PubMed

Insights

Mortality from chronic ischemic heart disease (IHD) in patients with atrial fibrillation (AF) has increased significantly in the U.S. between 1999 and 2023, particularly in males and non-Hispanic Whites.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia often co-existing with chronic ischemic heart disease (IHD).
  • This co-existence increases the risk of adverse cardiovascular events and mortality.
  • Understanding mortality trends is crucial for public health interventions.

Purpose of the Study:

  • To analyze trends in chronic IHD-related mortality among patients with AF in the U.S. from 1999 to 2023.
  • To identify demographic and geographic disparities in these mortality trends.

Main Methods:

  • Retrospective analysis of death records from the CDC WONDER database (adults aged 65+).
  • Examined deaths with chronic IHD as the underlying cause and AF as a contributing factor.
  • Calculated age-adjusted mortality rates (AAMR) and annual percent changes (APC).

Main Results:

  • AF was noted in nearly 460,196 deaths attributed to chronic IHD.
  • Age-adjusted mortality rates (AAMR) increased from 38.2 in 1999 to 52.2 in 2023.
  • Mortality rates were higher in males, non-Hispanic Whites, non-metropolitan areas, and the Northeast region.

Conclusions:

  • There is a concerning rise in chronic IHD mortality among AF patients.
  • Targeted interventions and resource allocation are needed for high-risk demographic and geographic groups.
  • Addressing these disparities is essential for improving cardiovascular outcomes.
Abstract

Keywords:
CDC WONDERatrial fibrillationischemic heart disease

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