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Associations of Baseline and Changes in Intrinsic Capacity With Incident Cardiovascular Disease: A Multicohort Study

Lulu Tang1,2, Changcui Qiu1,2, Xiaoli Yu2

  • 1Tongji University School of Medicine Shanghai China.

Journal of the American Heart Association
|February 3, 2026
PubMed

Insights

Declines in intrinsic capacity (IC), encompassing physical and mental abilities, are linked to increased cardiovascular disease (CVD) risk. Monitoring IC may help prevent CVD.

Area of Science:

  • Gerontology
  • Epidemiology
  • Public Health

Background:

  • Cardiovascular disease (CVD) is a leading global cause of death.
  • Intrinsic capacity (IC) is a composite measure of an individual's physical and mental capabilities.
  • The association between IC status, changes in IC, and incident CVD risk requires further investigation.

Purpose of the Study:

  • To examine the relationship between baseline intrinsic capacity (IC) and the risk of developing cardiovascular disease (CVD).
  • To investigate how changes in IC over time impact the risk of incident CVD.
  • To analyze these associations across diverse, nationally representative aging cohorts.

Main Methods:

  • Utilized data from four large, international aging cohorts: CHARLS, HRS, MHAS, and SHARE.
  • Assessed intrinsic capacity (IC) across five domains: locomotion, cognition, vitality, sensory, and psychology.
  • Employed Cox proportional hazards models to analyze the risk of incident CVD based on IC status and changes.

Main Results:

  • Individuals with impairments in two or more IC domains at baseline showed a significantly higher risk of incident CVD.
  • Participants exhibiting stable impaired IC over time had elevated CVD risks compared to those with robust IC.
  • Specific hazard ratios (HRs) indicated increased CVD risk associated with IC impairments across all cohorts.

Conclusions:

  • Both baseline intrinsic capacity (IC) impairments and sustained impairments are significantly associated with an increased risk of cardiovascular disease (CVD).
  • Regular assessment and monitoring of intrinsic capacity (IC) may serve as a preventative strategy for cardiovascular disease (CVD).
Abstract

Keywords:
cardiovascular diseaseintrinsic capacitymiddle‐aged and older adultsmulticohort

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