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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Updated: Feb 5, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
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Culture of Bladder Cancer Organoids as Precision Medicine Tools

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Deep Learning-Powered Scalable Cancer Organ Chip for Cancer Precision Medicine.

Yu-Chieh Yuan1, Beibei Xu2, Jenna McCormack1

  • 1Xellar Biosystems, Boston, Massachusetts, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|February 3, 2026
PubMed
Summary
This summary is machine-generated.

A novel Organ Chip (OC) platform offers a scalable, low-cost solution for functional precision oncology. This system enables high-throughput drug sensitivity testing using patient-derived models, closely aligning with clinical outcomes.

Keywords:
drug screeningin silico stainingorgan chipprecision medicine

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Area of Science:

  • Biotechnology
  • Oncology
  • Microfluidics

Background:

  • Functional precision oncology aims to personalize cancer treatment by testing therapies on patient-derived models.
  • Existing models like patient-derived xenografts (PDXs) and patient-derived organoids (PDOs) face challenges including cost, time, scalability, and TME recapitulation.

Purpose of the Study:

  • To develop a scalable, low-cost Organ Chip (OC) platform for functional precision oncology.
  • To overcome the limitations of current patient-derived models for drug sensitivity testing.

Main Methods:

  • Fabrication of an Organ Chip (OC) platform from thermoplastics using injection molding.
  • Utilized a patented channel geometry and surface treatment for barrier-free hydrogel confinement via capillary pinning.
  • Integrated deep learning for label-free phenotypic analysis and drug response prediction.

Main Results:

  • Demonstrated a scalable, low-cost OC platform supporting diverse matrices and co-cultures with robust imaging.
  • Successfully performed drug sensitivity testing on cell lines and primary cells, with results aligning to clinical outcomes.
  • Developed a deep learning model for accurate, longitudinal, label-free phenotypic analysis.

Conclusions:

  • The developed Organ Chip (OC) system addresses key technical barriers in functional precision oncology.
  • This platform provides a promising framework for high-throughput, patient-relevant drug testing.
  • The integrated system enhances sensitivity and enables label-free analysis for personalized cancer therapy.