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Innovative Biotechnological Strategies for Sustainable Myo-Inositol Production and Application.
Xuguo Duan1,2, Jinbo Zhang1,2, Yang Zhao1,2
1State Key Laboratory for Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing 210037, China.
Journal of Agricultural and Food Chemistry
|February 3, 2026
Summary
This review explores biotechnological methods for producing myo-inositol, a valuable compound. It highlights enzyme cascades and microbial cell factories to create sustainable and cost-effective biomanufacturing processes.
Area of Science:
- Biotechnology and Industrial Microbiology
- Biochemical Engineering
Background:
- Myo-inositol is a high-value cyclic polyol with increasing demand across pharmaceutical, food, feed, and cosmetic industries.
- Traditional production methods for myo-inositol are associated with high pollution levels.
- There is a growing need for sustainable and efficient alternatives to conventional manufacturing processes.
Purpose of the Study:
- To systematically review the latest biotechnological advances for myo-inositol production.
- To identify and analyze bottlenecks in current biomanufacturing strategies.
- To provide a roadmap for sustainable and cost-competitive myo-inositol bioproduction.
Main Methods:
- Review of multienzyme cascade systems utilizing immobilized reactors, microspheres, capsules, and biofilms for carbohydrate conversion.
- Examination of microbial cell-factory strategies, including chassis benchmarking (E. coli, P. pastoris, K. marxianus, cyanobacteria), carbon-flux redirection, and dynamic regulatory circuits.
- Analysis of cofactor regeneration, enzyme thermostability, substrate specificity, product inhibition, and downstream processing.
Main Results:
- Multienzyme cascades demonstrate enhanced stability, reusability, and space-time yields through innovative reactor designs.
- Microbial cell factories show potential through optimized chassis, synergistic feeding strategies, and advanced regulatory circuits.
- Key bottlenecks such as cofactor imbalance and enzyme limitations are identified, with proposed solutions like cofactor regeneration and modular process design.
Conclusions:
- Biotechnological approaches, including enzyme cascades and microbial cell factories, offer a sustainable alternative to traditional myo-inositol production.
- Addressing identified bottlenecks is crucial for improving efficiency and cost-competitiveness.
- This review provides a comprehensive guide for future research towards greener and economically viable myo-inositol biomanufacturing systems.
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