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Short Arg- and Trp-Rich Lipopeptides Kill Resistant Bacterial Pathogens via Effective Membrane Disruption

Tianhao Ge1,2, Mingrui Liao1, Ke Fa1

  • 1Biological Physics Laboratory, Department of Physics and Astronomy, University of Manchester, Manchester M13 9PL, U.K.

Biomacromolecules
|February 3, 2026
PubMed
Summary

New lipopeptides show potent antimicrobial activity against resistant bacteria like E. coli and S. aureus by disrupting cell membranes. Techniques like neutron reflection confirmed their mechanism, aiding in the fight against antimicrobial resistance (AMR).

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