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Nasopharyngeal Methicillin-Resistant Staphylococcus aureus Carriage and Risk of Percutaneous Endoscopic

Islam Mohamed1, Samuel Kim2, Mira Bhatia2

  • 1Department of Gastroenterology and Hepatology, University of Missouri Columbia, Columbia, Missouri, USA, islamh3255@gmail.com.

Digestive Diseases (Basel, Switzerland)
|February 3, 2026
PubMed

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) colonization significantly increases the risk of percutaneous endoscopic gastrostomy (PEG) site infections. Screening for MRSA before PEG insertion is crucial for infection prevention and patient safety.

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Medical Microbiology

Background:

  • Percutaneous endoscopic gastrostomy (PEG) is vital for long-term enteral nutrition.
  • PEG insertion poses infection risks, notably methicillin-resistant Staphylococcus aureus (MRSA) peristomal infections.

Purpose of the Study:

  • To systematically review and meta-analyze the association between MRSA colonization and PEG-related infections.
  • To evaluate the risk of PEG site infections in patients colonized with MRSA.

Main Methods:

  • Systematic search of Embase, Medline, Cochrane, and Scopus databases.
  • Meta-analysis of five studies involving 286 patients.
  • Calculation of odds ratios (OR) using a random-effects model.

Main Results:

  • MRSA colonization was significantly linked to a higher risk of PEG-related peristomal infection (OR: 24.31).
  • Low heterogeneity (I² statistic) indicates robust findings.
  • 77 of 286 patients were nasopharyngeal MRSA-positive.

Conclusions:

  • Nasopharyngeal MRSA colonization is a strong predictor of PEG site infections.
  • Pre-PEG insertion MRSA screening and infection control are recommended for positive patients.
  • Further research is needed for tailored preventive strategies in MRSA-colonized individuals.
Keywords:
Meta-analysisMethicillin-resistant Staphylococcus aureus carriageNasopharyngealPercutaneous endoscopic gastrostomy-related infectionSystematic review

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