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Wedelolactone: Unveiling the Multifaceted Anti-Inflammatory Potential
Lu Zhang1, Di Liu2, Qiuyang Huang3
1College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.
Background:
Wedelolactone (WED) is a polyphenolic compound with a coumarin skeleton isolated from marigold. Despite its wide application in traditional medicine, its mechanisms of action and safety profile require further investigation.
Summary:
The key contributions of this review lie in: (1) the first systematic integration of WED's multi-target mechanisms across diseases through the AMPK/NF-κB/NLRP3 network; (2) clarification of its dose-effect relationship (effective therapeutic window: 5-100 mg/kg) and toxicity thresholds; (3) proposal of clinical translation strategies, including nanodelivery systems to address bioavailability issues. Recent studies revealed novel mechanisms such as WED's inhibition of ferroptosis via GPX4 and modulation of the FXR-bile acid axis, demonstrating efficacy in acute lung injury and liver fibrosis.
Key Messages:
This article provides a comprehensive framework integrating mechanistic insights and translational research for WED's clinical development.
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