Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

16.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.8K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

7.8K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.8K
Potential Energy00:52

Potential Energy

42.7K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.7K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.4K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.4K
Cell Potential and Free Energy02:58

Cell Potential and Free Energy

46.6K
Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
46.6K
The Resting Membrane Potential01:21

The Resting Membrane Potential

142.8K
Overview
142.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2019
Same author

Treatment of clinical T4 stage superior sulcus non-small cell lung cancer: a propensity-matched analysis of the surveillance, epidemiology, and end results database.

Bioscience reports·2019
Same author

Machine learning framework for assessment of microbial factory performance.

PloS one·2019
Same author

Low Pathogenic Avian Influenza A (H5N7) Virus Isolated from a Domestic Duck in Dongting Lake Wetland of China, 2016.

Virologica Sinica·2019
Same author

Nomograms for predicting survival outcomes in patients with primary tracheal tumors: a large population-based analysis.

Cancer management and research·2018
Same author

The role of metabolism in the pathogenesis of systemic sclerosis.

Metabolism: clinical and experimental·2018

Related Experiment Video

Updated: Feb 5, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

8.1K

Wedelolactone: Unveiling the Multifaceted Anti-Inflammatory Potential.

Lu Zhang1, Di Liu2, Qiuyang Huang3

  • 1College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.

Pharmacology
|February 3, 2026
PubMed
Summary

Wedelolactone (WED), a marigold compound, shows therapeutic potential by targeting multiple disease pathways via the AMPK/NF-κB/NLRP3 network. This review clarifies its effective dose, safety, and proposes nanodelivery for clinical use.

Keywords:
Anti-inflammatoryInflammationTherapeutic effectWedelolactone

More Related Videos

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages
08:34

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages

Published on: February 22, 2017

11.9K
Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

1.1K

Related Experiment Videos

Last Updated: Feb 5, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

8.1K
Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages
08:34

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages

Published on: February 22, 2017

11.9K
Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

1.1K

Area of Science:

  • Pharmacology
  • Natural Products
  • Drug Discovery

Background:

  • Wedelolactone (WED) is a coumarin-derived polyphenol from marigold with traditional medicinal uses.
  • Its precise mechanisms of action and safety profile require comprehensive investigation for modern therapeutic applications.

Purpose of the Study:

  • To systematically integrate WED's multi-target mechanisms across various diseases, focusing on the AMPK/NF-κB/NLRP3 pathway.
  • To clarify the dose-effect relationship and toxicity thresholds of WED.
  • To propose strategies for clinical translation, including addressing bioavailability challenges with nanodelivery systems.

Main Methods:

  • Systematic literature review and mechanistic pathway analysis.
  • Integration of data on dose-response and toxicity studies.
  • Exploration of novel therapeutic targets and delivery systems.

Main Results:

  • WED modulates key cellular pathways including AMPK/NF-κB/NLRP3, ferroptosis (via GPX4), and the FXR-bile acid axis.
  • An effective therapeutic window for WED was identified as 5-100 mg/kg.
  • WED demonstrated efficacy in preclinical models of acute lung injury and liver fibrosis.

Conclusions:

  • This review provides a unified framework for understanding WED's complex mechanisms of action.
  • WED exhibits promising therapeutic potential, supported by defined dosage and safety parameters.
  • Nanodelivery systems offer a viable strategy to enhance WED's bioavailability for clinical translation.