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Identification of Protein Interacting Partners Using Tandem Affinity Purification
Published on: February 25, 2012
Improving HIV assisted partner services outcomes by eliciting additional partners after the initial encounter
George Otieno1, Sarah Masyuko2,3, Unmesha Roy Paladhi4,5
1PATH-Kenya, Kisumu, Kenya.
Continuing partner services after initial HIV diagnosis significantly increases the identification of male partners at higher HIV risk. Ongoing elicitation during follow-up visits led to more new HIV diagnoses compared to initial partner naming.
Area of Science:
- Public Health
- Epidemiology
- HIV/AIDS Research
Background:
- Assisted partner services (APS) are crucial for HIV prevention, but partner elicitation often occurs only at initial diagnosis.
- Index clients may be hesitant to disclose all partners initially, limiting the effectiveness of traditional APS.
- The benefits of sustained partner elicitation beyond the initial HIV diagnosis visit are not well understood.
Purpose of the Study:
- To evaluate the impact of ongoing partner elicitation in assisted partner services (APS) on identifying male partners at increased HIV risk.
- To compare the characteristics and HIV diagnosis rates of partners named during initial versus follow-up visits within an APS program.
- To assess the association between continued partner elicitation and the number of new HIV diagnoses.
Main Methods:
- A prospective study involving 872 female index clients in western Kenya who accepted APS.
- Partners were elicited at initial HIV diagnosis and during 12 months of follow-up clinic visits.
- Multivariable Poisson Generalized Estimated Equation models were used to analyze data on partner characteristics and HIV diagnoses.
Main Results:
- A total of 3461 male partners were named, with 2920 successfully contacted and HIV tested.
- Partners named at follow-up visits were significantly more likely to be newly diagnosed with HIV (17.5%) compared to those named at the initial visit (4.9%).
- Partners named at follow-up visits were 3.9 times more likely to be newly diagnosed with HIV and reported higher-risk behaviors.
Conclusions:
- Continuing partner elicitation for APS for 12 months after initial HIV diagnosis substantially increases the identification of male partners at increased HIV risk.
- Ongoing partner services are more effective in diagnosing new HIV infections than relying solely on initial partner disclosure.
- Sustained APS efforts are vital for comprehensive HIV case finding and prevention strategies.
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