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Updated: Feb 5, 2026

Author Spotlight: Integrating 2D-HPLC-MS and Molecular Networking in Natural Medicine Analysis
Published on: December 8, 2023
Rapid identification of chemical components in Polygonatum kingianum Collett & Hemsl. based on UHPLC-Q-Exactive
Qing Li1, Kailin Li2, Jiatong Yang2
1School of Pharmacy, Baotou Medical College, Baotou 014000, China; School of Pharmaceutical Science, Hunan University of Medicine, Huaihua, Hunan 418000, China.
Abstract:
Polygonatum kingianum Collett & Hemsl. (PK) is a plant dually used as both medicine and food, renowned in traditional medicine for its abilities to replenish qi, nourish yin, moisten the lungs, and benefit the kidneys. Previous investigations have indicated that its chemical composition encompasses steroidal saponins, polysaccharides, and flavonoids. However, the PK's chemical components is still scarce. Therefore, it is essential to establish a systematic method for the identifying and characterizing its chemical components. In this study, a total of 153 chemical components, including 37 peptides, 26 organic acids, 20 saponins, 19 flavonoids, 7 amino acids, 7 nucleotides, 7 lipids, 6 terpenoids and other classes, was identified by UHPLC-Q-Exactive Orbitrap MS with molecular networking. This analysis revealed 118 new compounds from PK, which distinctly lays the foundation for the scientific exploration of the pharmacodynamic substance basis of PK as well as the development and application of the resources derived from it.
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