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Novel Object Exploration as a Potential Assay for Higher Order Repetitive Behaviors in Mice
Published on: August 20, 2016
Repetitive and restricted behaviors, habits, body-focused repetitive behaviors, and motor stereotypies
Harvey S Singer1, Sahar Mahate2, Christina Morris-Berry1
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Neurology, Kennedy Krieger Institute, Baltimore, MD, United States.
Abstract:
Movement disorder definitions that include the clinical characteristics "sudden, rapid, repetitive, brief, and involuntary" are not limited to motor tic disorders. Hence, it is essential that caregivers be aware of other relatively common conditions that could be confused with the diagnosis of tics. Included in this differential are entities such as repetitive and restricted behaviors (RRBs), habits, body-focused repetitive behaviors (BFRBs), and motor stereotypies. The importance of separation of these individual conditions is further emphasized by the recognition that they can be coexisting problems in individuals with tic disorders, and thus therapeutic approaches may differ. For example, some individuals diagnosed with Tourette syndrome have co-occurring complex motor stereotypies or recurring skin picking, nail biting, and hair pulling. This chapter reviews the definition of a movement disorder and the evolving entity labeled as RRBs. It also contains a more in-depth review of our knowledge regarding the clinical features, etiology, pathophysiology, and therapeutic approaches for the more specific diagnoses including habits, BFRBs, and stereotypies.
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