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Updated: Feb 5, 2026

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

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Subclinical cardiac dysfunction detected by speckle-tracking echocardiography in children with drug-resistant

Mahmoud M Noureldeen1, Mohamed Mabrouk Tohamy2, Osama Ezzat Botrous3

  • 1Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. mmpediatrics@med.bsu.edu.eg.

Pediatric Research
|February 3, 2026
PubMed

Insights

Pediatric drug-resistant epilepsy (DRE) is linked to significant cardiac dysfunction, particularly impaired left ventricular systolic function and global longitudinal strain. Early detection of these subclinical cardiac abnormalities is possible with speckle tracking echocardiography (STE).

Area of Science:

  • Pediatric Cardiology
  • Neurology
  • Biomedical Engineering

Background:

  • Pediatric epilepsy can negatively impact cardiac function.
  • This study investigates cardiac outcomes in children with controlled and drug-resistant epilepsy (DRE).

Purpose of the Study:

  • To compare cardiac function in pediatric DRE versus drug-responsive epilepsy.
  • To identify cardiac abnormalities in children with epilepsy.
  • To explore correlations between cardiac function and epilepsy disease course or treatment.

Main Methods:

  • Eighty-nine children (30 DRE, 30 drug-responsive, 30 controls) underwent ECG and echocardiography.
  • Speckle tracking echocardiography (STE) assessed left ventricular (LV) volumes, ejection fraction (EF), fractional shortening (FS), and global longitudinal strain (GLS).

Main Results:

  • ECG findings were similar across groups.
  • Children with DRE showed significantly lower LV volumes, FS, and EF compared to controls.
  • LV GLS was significantly reduced in DRE compared to drug-responsive epilepsy and controls, correlating with medication burden and time since last seizure.

Conclusions:

  • Children with DRE exhibit significant cardiac dysfunction, including impaired systolic function and GLS.
  • STE is valuable for early detection of subclinical cardiac abnormalities in DRE.
  • Routine cardiac monitoring using STE is recommended for children with DRE.
Abstract

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