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D2Rs Agonist Ropinirole Cooperates with Metformin to Modulate Thermogenesis and Ameliorate Obesity-Related Metabolic

Bangrui Huang1,2,3,4, Daowei Liu1,2, Fakun Jiang1

  • 1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, China.

Diabetes & Metabolism Journal
|February 3, 2026
PubMed
Abstract

Insights

Combining metformin and ropinirole effectively treats obesity and metabolic disorders by enhancing energy expenditure and improving mitochondrial function. This drug combination offers a promising new approach for metabolic disorder treatment.

Area of Science:

  • Metabolic disorders research
  • Pharmacology
  • Obesity treatment

Background:

  • Metabolic disorders pose significant health challenges due to prevalence and limited treatment options.
  • Drug repurposing is a viable strategy for expedited intervention.
  • Obesity-related metabolic dysfunction requires novel therapeutic approaches.

Purpose of the Study:

  • To investigate the efficacy of combining metformin and ropinirole for anti-obesity effects.
  • To elucidate the underlying mechanisms of this drug combination in metabolic disorders.

Main Methods:

  • In vivo and in vitro studies evaluating metformin and ropinirole combination therapy.
  • Assessment of body weight, metabolic parameters (hyperglycemia, dyslipidemia, insulin resistance), and energy expenditure.
  • Analysis of adipose tissue (inguinal white adipose tissue and brown adipose tissue) and mitochondrial function.

Main Results:

  • Combination therapy significantly reduced body weight and improved metabolic parameters compared to monotherapy.
  • Increased energy expenditure, adipose tissue browning, and enhanced mitochondrial function were observed.
  • The mechanism involves dopamine-mediated sympathetic nerve activity and direct metformin action on adipose tissue.

Conclusions:

  • Metformin and ropinirole combination therapy demonstrates amplified effectiveness in treating obesity and related metabolic disorders.
  • The synergistic effect is linked to dopamine-controlled sympathetic activity and metformin's impact on mitochondrial function in adipose tissue.
  • This combination presents a novel therapeutic perspective for clinical co-treatment strategies.
Keywords:
Metabolic diseasesMetforminMitochondriaRopiniroleThermogenesis

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